Avoiding Addiction Through Proper Opioid Dosing
by Kevin Graham
The miracle of opioid pain relief is fatally limited by tolerance, addiction, and respiratory depression. Buprenorphine, when combined with a mu agonist, results in game-changing effects. Patients experience potent, dose-related analgesia from the agonist, but have NO euphoria. The therapeutic window is widened. Patients unable to control their use of a mu agonist alone gain that control when on buprenorphine. And most exciting, buprenorphine indefinitely anchors tolerance, maintaining analgesia WITHOUT DOSE ESCALATION. This finding offers huge implications for pain management and <a href="http://525md.com">opioid dosing</a>.
Opioid medications are prescribed for patients with painful conditions and the response is typically excellent pain relief. There are side effects which may include constipation, tolerance, depression, and sedation. With chronic pain affecting 15% of the US population, doctors are prescribing narcotic medications with alarming frequency.
However, naltrexone is used mainly as a drug that acts to control alcohol dependence and addiction. This action of naltrexone occurs in high doses. Low dose naltrexone is used to treat a number of illnesses including Crohn's disease, multiple sclerosis (MS) and fibromyalgia. Whilst some degree of extensive research into the effect of the drug and Crohn's disease has been done, the use of this drug on multiple sclerosis and fibromyalgia still need much investigation.
Patients in chronic pain are likely to take opioids for multiple years. A study done at the Universities of Washington and Arkansas showed when patients are prescribed opioids for chronic pain, they are likely to still be taking them 5 years later.
Interestingly, there were 2 factors that lead to the continued usage. One was if the patient had been prescribed the drugs before, and the other was if the patients were prescribed doses in excess of 120 milligrams of morphine. Of note, that is a hefty dose.
Opioid-induced hyperalgesia is a condition that can result from long-term opioid use. It represents a heightened perception of pain and can make one feel worse with more pain sensation. The solution to this problem is a decrease or discontinuation of the medication which should be accomplished under medical supervision. The discontinuation can result in less pain than while on the medications.
Sleep is affected significantly by opioids. A large review of studies was published in Postgraduate Medicine looking at the effect of narcotics on sleeping patterns. What popped out? Well, opiate users displayed significant incidence of insomnia, arousals, and wakefulness.
There was also a temporary absence of REM sleep, which is the type of sleep people go into as they go deeper into sleep. So narcotics appear to affect both the quality and quantity of sleep, which is obviously suboptimal for patients who have painful conditions and need sleep for regeneration and healing potential.
By blending drugs, abusers will risk overdose and dangerous interactions. Permitting this harmful experimentation encourages and enables addiction. If someone you love or yourself is abusing methadone, quit before you cause further harm.
When you are looking for the facts about <a href="http://525md.com">opioid dosing</a>, come to the web pages online today. More details are available at http://525md.com now.
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New Unique Article!
Title: Avoiding Addiction Through Proper Opioid Dosing
Author: Kevin Graham
Email: nathanwebster335@live.com
Keywords: opioid dosing
Word Count: 481
Category: Medicine
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